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00.250.50.7511.251.51.752+Deftereos (RCT)77%0.23 [0.03-1.97]death1/554/50Improvement, RR [CI]TreatmentControlLopes (DB RCT)80%0.20 [0.01-4.03]death0/362/36Brunetti73%0.27 [0.08-0.89]death3/3311/33Scarsi85%0.15 [0.06-0.37]death122140Pinzón35%0.65 [0.34-1.21]death14/14523/156Sandhu42%0.58 [0.40-0.85]death16/3463/78Rodriguez-Nava6%0.94 [0.61-1.47]death16/5285/261Tardif (DB RCT)44%0.56 [0.19-1.67]death5/2,2359/2,253Horby (RCT)-1%1.01 [0.93-1.10]death1,173/5,6101,190/5,730Tau​2 = 0.19; I​2 = 76.0%Late treatment43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvementAll studies43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvement9 colchicine COVID-19 studiesc19colchicine.com 7/28/21Tau​2 = 0.19; I​2 = 76.0%; Z = 2.77 (p = 0.0028)Effect extraction pre-specifiedLower RiskIncreased Risk
5/18
Late Horby et al., medRxiv, doi:10.1101/2021.05.18.21257267 (Preprint) death, ↑1.0%, p=0.77 Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Details   RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, mean 9 days after symptom onset. Baseline oxygen requirements unknown (data is provided but combined with "none&qu..
3/14
Meta Hariyanto et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13488 (Peer Reviewed) (meta analysis) meta-analysis Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Details   Meta analysis concluding that colchicine can reduce severity and mortality in COVID‐19 patients, mortality OR 0.43 [0.32-0.58].
1/27
Late Tardif et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00222-8 (preprint 1/27) (Peer Reviewed) death, ↓43.9%, p=0.30 Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
Details   RCT for relatively low risk outpatients, 2235 treated with colchicine a mean of 5.3 days after the onset of symptoms, and 2253 controls, showing lower mortality, ventilation, and hospitalization with treatment. NCT04322682.
11/5
Late Rodriguez-Nava et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes (Peer Reviewed) death, ↓5.5%, p=0.87 Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study
Details   Retrospective 313 patients, mostly critical stage and mostly requiring respiratory support. Confounding by indication likely.
10/27
Late Sandhu et al., Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2020/8865954 (Peer Reviewed) death, ↓41.7%, p=0.0006 A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection
Details   Prospective cohort study of hospitalized patients in the USA, 34 treated with colchicine, showing lower mortality and intubation with treatment.
10/23
Late Pinzón et al., Research Square, doi:10.21203/rs.3.rs-94922/v1 (Preprint) death, ↓34.5%, p=0.18 Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine in Colombia
Details   Retrospective 301 pneumonia patients in Colombia showing lower mortality with colchicine treatment.
9/14
Late Scarsi et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217712 (Peer Reviewed) death, ↓84.9%, p<0.0001 Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome
Details   Retrospective 122 colchicine patients and 140 control patients in Italy, showing lower mortality with treatment.
9/14
Late Brunetti et al., J. Clin. Med., 9:9, 2961, doi:10.3390/jcm9092961 (Peer Reviewed) death, ↓72.7%, p=0.03 Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19
Details   PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment.
8/12
Late Lopes et al., RMD Open, doi:10.1136/rmdopen-2020-001455 (preprint 8/12) (Peer Reviewed) death, ↓80.0%, p=0.49 Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial
Details   RCT with 36 colchicine and 36 control patients, showing reduced length of hospitalization and oxygen therapy with treatment.
6/24
Late Deftereos et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.13136 (Peer Reviewed) death, ↓77.3%, p=0.19 Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial
Details   RCT with 55 patients treated with colchicine and 50 control patients, showing lower mortality and ventilation with treatment. NCT04326790.
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