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Other Treatments Global Adoption
Colchicine COVID-19 studies. Recently added: Alsultan Zein. Colchicine has been officially adopted for early treatment in 1 country. Submit updates/corrections.
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Jan 17
Early, Late, PrEP, PEP Covid Analysis (Preprint) (meta analysis)
Colchicine for COVID-19: real-time meta analysis of 13 studies
Details   • Statistically significant improvements are seen for mortality and hospitalization. 5 studies from 4 different countries show statistically significant improvements in isolation (4 for the most serious outcome). • Meta analysis using t..
Jan 12
Meta Zein et al., Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395 (Peer Reviewed) (meta analysis)
Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis
Details   Systematic review and meta analysis showing that colchicine was associated with lower mortality in COVID-19 patients: All studies: RR 0.66 [95%CI 0.53, 0.83], p < 0.001; I2: 42% RCTs: RR 0.81 [95%CI 0.54, 1.20], p = 0.29; I2: 10% The RC..
Dec 31
Late Alsultan et al., Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2021/2129006 (Peer Reviewed)
death, ↓35.7%, p=0.70
Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
Details   Small RCT 49 severe condition hospitalized patients in Syria, showing lower mortality with colchicine and shorter hospitalization time with both colchicine and budesonide (all of these were not statistically significant).
Sep 23
Late Dorward et al., medRxiv, doi:2021.09.20.21263828 (Preprint)
hosp./death, ↑29.8%, p=0.66
Colchicine for COVID-19 in adults in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
Details   Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580.
Jul 10
Late Gaitán-Duarte et al., medRxiv, doi:10.1101/2021.07.06.21260085 (Preprint)
death, ↓19.0%, p=0.43
Effectiveness of Rosuvastatin plus Colchicine, Emtricitabine/Tenofovir and a combination of them in Hospitalized Patients with SARS Covid-19
Details   RCT 633 hospitalized patients in Colombia, 153 treated with colchicine + rosuvastatin, not showing statistically significant differences in outcomes. Improved results were seen with the combination of emtricitabine/tenofovir disoproxil + ..
May 18
Late Recovery Collaborative Group, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00435-5 (preprint 5/18/2021) (Peer Reviewed)
death, ↑1.0%, p=0.77
Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Details   RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, median 9 days after symptom onset. Baseline oxygen requirements unknown (data is provided but combined with "none&..
Mar 14
Meta Hariyanto et al., Clinical and Experimental Pharmacology and Physiology, doi:10.1111/1440-1681.13488 (Peer Reviewed) (meta analysis)
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis
Details   Meta analysis concluding that colchicine can reduce severity and mortality in COVID‐19 patients, mortality OR 0.43 [0.32-0.58].
Jan 27
Late Tardif et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00222-8 (preprint 1/27) (Peer Reviewed)
death, ↓43.9%, p=0.30
Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
Details   RCT for relatively low risk outpatients, 2235 treated with colchicine a mean of 5.3 days after the onset of symptoms, and 2253 controls, showing lower mortality, ventilation, and hospitalization with treatment. NCT04322682.
Nov 5
Late Rodriguez-Nava et al., Mayo Clinic Proceedings: Innovations, Quality & Outcomes (Peer Reviewed)
death, ↓5.5%, p=0.87
Clinical characteristics and risk factors for mortality of hospitalized patients with COVID-19 in a community hospital: A retrospective cohort study
Details   Retrospective 313 patients, mostly critical stage and mostly requiring respiratory support. Confounding by indication likely.
Oct 27
Late Sandhu et al., Canadian Journal of Infectious Diseases and Medical Microbiology, doi:10.1155/2020/8865954 (Peer Reviewed)
death, ↓41.7%, p=0.0006
A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection
Details   Prospective cohort study of hospitalized patients in the USA, 34 treated with colchicine, showing lower mortality and intubation with treatment.
Oct 23
Late Pinzón et al., Research Square, doi:10.21203/ (Preprint)
death, ↓34.5%, p=0.18
Clinical Outcome of Patients with COVID-19 Pneumonia Treated with Corticosteroids and Colchicine in Colombia
Details   Retrospective 301 pneumonia patients in Colombia showing lower mortality with colchicine treatment.
Sep 21
Late Salehzadeh et al., Research Square, doi:10.21203/ (Preprint)
hosp. time, ↓22.7%, p=0.001
The Impact of Colchicine on The COVID-19 Patients; A Clinical Trial Study
Details   Open label RCT with 100 hospitalized patients in Iran, 50 treated with colchicine, showing shorter hospitalization time. There were no deaths. IRCT20200418047126N1.
Sep 14
Late Scarsi et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217712 (Peer Reviewed)
death, ↓84.9%, p<0.0001
Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome
Details   Retrospective 122 colchicine patients and 140 control patients in Italy, showing lower mortality with treatment.
Sep 14
Late Brunetti et al., J. Clin. Med., 9:9, 2961, doi:10.3390/jcm9092961 (Peer Reviewed)
death, ↓72.7%, p=0.03
Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19
Details   PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment.
Aug 12
Late Lopes et al., RMD Open, doi:10.1136/rmdopen-2020-001455 (preprint 8/12) (Peer Reviewed)
death, ↓80.0%, p=0.49
Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial
Details   RCT with 36 colchicine and 36 control patients, showing reduced length of hospitalization and oxygen therapy with treatment.
Jun 24
Late Deftereos et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.13136 (Peer Reviewed)
death, ↓77.3%, p=0.19
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial
Details   RCT with 55 patients treated with colchicine and 50 control patients, showing lower mortality and ventilation with treatment. NCT04326790.
Please send us corrections, updates, or comments. Vaccines and treatments are both valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases mortality, morbidity, collateral damage, and the risk of endemic status. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. WCH and FLCCC provide treatment protocols.
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