Absalón-Aguilar, 116 patient colchicine late treatment RCT: 29% lower mortality [p=0.74], 17% lower progression [p=0.67], and 13% worse recovery [p=0.59] https://c19p.org/absalonaguilar
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Colchicine Is Safe Though Ineffective in the Treatment of Severe COVID-19: a Randomized Clinical Trial (COLCHIVID)
et al., Journal of General Internal Medicine, doi:10.1007/s11606-021-07203-8
Very late stage RCT with 56 colchicine and 60 control patients in Mexico, showing no significant differences.
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risk of death, 28.6% lower, RR 0.71, p = 0.74, treatment 4 of 56 (7.1%), control 6 of 60 (10.0%), NNT 35.
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progression to critical or death, 17.0% lower, OR 0.83, p = 0.67, treatment 56, control 60, primary outcome, RR approximated with OR.
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risk of no recovery, 13.0% higher, RR 1.13, p = 0.59, treatment 56, control 60, Kaplan–Meier.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Absalón-Aguilar et al., 9 Nov 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Mexico, peer-reviewed, 18 authors.
Late treatment
is less effective
is less effective
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