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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 36% Improvement Relative Risk Hospitalization time 20% no CI Colchicine  Alsultan et al.  LATE TREATMENT  RCT Is late treatment with colchicine beneficial for COVID-19? RCT 35 patients in Syria Trial underpowered to detect differences c19early.org Alsultan et al., Interdisciplinary Per.., Dec 2021 Favors colchicine Favors control

Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial

Alsultan et al., Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2021/2129006
Dec 2021  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000024 from 52 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Small RCT 49 severe condition hospitalized patients in Syria, showing lower mortality with colchicine and shorter hospitalization time with both colchicine and budesonide (all of these were not statistically significant).
Although the 36% lower mortality is not statistically significant, it is consistent with the significant 29% lower mortality [19‑39%] from meta analysis of the 41 mortality results to date.
Study covers colchicine and budesonide.
risk of death, 35.7% lower, RR 0.64, p = 0.70, treatment 3 of 14 (21.4%), control 7 of 21 (33.3%), NNT 8.4.
hospitalization time, 20.0% lower, relative time 0.80, treatment 14, control 21.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Alsultan et al., 31 Dec 2021, Randomized Controlled Trial, Syria, peer-reviewed, 11 authors, dosage 2mg day 1, 1mg days 2-5.
This PaperColchicineAll
Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
Mohammad Alsultan, Ameer Obeid, Omar Alsamarrai, Mohamed Taher Anan, Aliaa Bakr, Nawwar Soliman, Mamdoh Kurdy, Muhannad Hag Mosa, Zain Saleh, Fatima Hujij, Jafar Barhoum
Interdisciplinary Perspectives on Infectious Diseases, doi:10.1155/2021/2129006
COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. e severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to investigate the efficacy of two agents (oral colchicine and budesonide inhaler) in COVID-19 infection management, compared with supportive care alone. 77 patients were admitted to the isolation section of Al Assad University Hospital, between the 1 st of August and the 30 th of August. A total of 49 patients were included in this randomized control trial, after excluding ineligible patients. e random sample was divided into three groups; the first group was supportive care plus colchicine, the second group was supportive care plus budesonide inhaler, and the control group was supportive care alone. PaO2/FiO2 was improved in the budesonide group, higher than the supportive and colchicine groups. e median hospitalization days were shorter when using colchicine or budesonide, opposed to supportive care alone (8 vs 10 days, respectively). 34 patients (69.3%) were discharged, and 27 patients (55.1%) were followed up until they were weaned from oxygen and made a complete recovery. ere was a significant decrease in mortality with colchicine (3 patients; 21.4%) compared with supportive care (7 patients; 33.3%) and the budesonide group (5 patients; 35.7%).
Conflicts of Interest e authors declare that they have no conflicts of interest.
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Late treatment
is less effective
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