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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 73% Improvement Relative Risk Hospital discharge 73% c19colchicine.com/brunetti.html Favors colchicine Favors control
14 September 2020 - Late treatment study
Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19
Brunetti et al., J. Clin. Med., 9:9, 2961, doi:10.3390/jcm9092961 (Peer Reviewed)
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PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment.
risk of death, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), NNT 4.1, PSM.
risk of no hospital discharge, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), NNT 4.1, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Brunetti et al., 9/14/2020, retrospective, propensity score matching, USA, North America, peer-reviewed, 7 authors.
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