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0 0.5 1 1.5 2+ Mortality 73% Improvement Relative Risk Discharge 73% c19colchicine.com Brunetti et al. Colchicine for COVID-19 LATE Favors colchicine Favors control
Brunetti, 66 patient colchicine late treatment PSM study: 73% lower mortality [p=0.03] and 73% higher hospital discharge [p=0.03] https://c19p.org/brunetti
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Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19
Brunetti et al., J. Clin. Med., 9:9, 2961, doi:10.3390/jcm9092961
14 Sep 2020    Source   PDF   Share   Tweet
PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment.
risk of death, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), NNT 4.1, PSM.
risk of no hospital discharge, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), NNT 4.1, PSM.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Brunetti et al., 9/14/2020, retrospective, propensity score matching, USA, North America, peer-reviewed, 7 authors.
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Late treatment
is less effective
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