et al., J. Clin. Med., 9:9, 2961,
PSM matched analysis from consecutive hospitalized patients, with 33 colchicine and 33 control matched patients, showing lower mortality with treatment.
Brunetti et al., 9/14/2020, retrospective, propensity score matching, USA, North America, peer-reviewed, 7 authors.
risk of death, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), PSM.
risk of no hospital discharge, 72.7% lower, RR 0.27, p = 0.03, treatment 3 of 33 (9.1%), control 11 of 33 (33.3%), PSM.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.