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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 77% Improvement Relative Risk Mechanical ventilation 82% Clinical deterioration 87% c19colchicine.com/deftereos.html Favors colchicine Favors control
24 June 2020 - Late treatment study
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial
Deftereos et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2020.13136 (Peer Reviewed)
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RCT with 55 patients treated with colchicine and 50 control patients, showing lower mortality and ventilation with treatment. NCT04326790.
risk of death, 77.3% lower, RR 0.23, p = 0.19, treatment 1 of 55 (1.8%), control 4 of 50 (8.0%), NNT 16.
risk of mechanical ventilation, 81.8% lower, RR 0.18, p = 0.10, treatment 1 of 55 (1.8%), control 5 of 50 (10.0%), NNT 12.
risk of clinical deterioration, 87.4% lower, RR 0.13, p = 0.046, treatment 1 of 55 (1.8%), control 7 of 50 (14.0%), NNT 8.2, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Deftereos et al., 6/24/2020, Randomized Controlled Trial, Greece, Europe, peer-reviewed, 49 authors.
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