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0 0.5 1 1.5 2+ Mortality 12% primary Improvement Relative Risk Death/intubation 17% primary Death/intubation (b) 52% Mortality (b) 17% Death/intubation (c) 25% c19colchicine.com Diaz et al. NCT04328480 Colchicine RCT LATE TREATMENT Favors colchicine Favors control
Diaz, 1,279 patient colchicine late treatment RCT: 12% lower mortality [p=0.3] and 17% lower combined mortality/intubation [p=0.08] https://c19p.org/diaz2
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Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19
Diaz et al., JAMA Network Open, doi:10.1001/jamanetworkopen.2021.41328
29 Dec 2021    Source   PDF   Share   Tweet
Very late stage RCT (O2 88%, 84% on oxygen) with 1,279 hospitalized patients in Argentina, showing lower mortality and lower combined mortality/ventilation, statistically significant only for the combined outcome and per-protocol analysis. NCT04328480. COLCOVID.
risk of death, 12.0% lower, HR 0.88, p = 0.30, treatment 131 of 640 (20.5%), control 142 of 639 (22.2%), NNT 57, adjusted per study, Cox proportional hazards, primary outcome.
risk of death/intubation, 17.0% lower, HR 0.83, p = 0.08, treatment 160 of 640 (25.0%), control 184 of 639 (28.8%), NNT 26, adjusted per study, Cox proportional hazards, primary outcome.
risk of death/intubation, 52.0% lower, HR 0.48, p = 0.60, treatment 6 of 93 (6.5%), control 13 of 102 (12.7%), NNT 16, adjusted per study, subset not on supplemental oxygen, Cox proportional hazards.
risk of death, 17.0% lower, HR 0.83, p = 0.30, treatment 98 of 515 (19.0%), control 140 of 634 (22.1%), NNT 33, adjusted per study, PP, Cox proportional hazards.
risk of death/intubation, 25.0% lower, HR 0.75, p = 0.02, treatment 117 of 515 (22.7%), control 181 of 634 (28.5%), NNT 17, adjusted per study, PP, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: very late stage, oxygen saturation <90% at baseline.
Diaz et al., 12/29/2021, Randomized Controlled Trial, Argentina, South America, peer-reviewed, 101 authors, study period 17 April, 2020 - 28 March, 2021, trial NCT04328480.
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