Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580.
Dorward et al., 9/23/2021, Randomized Controlled Trial, United Kingdom, Europe, preprint, 21 authors.
risk of combined hospitalization/death, 29.8% higher, RR 1.30, p = 0.65, treatment 6 of 156 (3.8%), control 4 of 133 (3.0%), odds ratio converted to relative risk, concurrent randomisation.
risk of combined hospitalization/death, 22.1% lower, RR 0.78, p = 0.55, treatment 6 of 156 (3.8%), control 119 of 1145 (10.4%), odds ratio converted to relative risk, including control patients before the colchicine arm started.
risk of disease progression, 6.0% lower, RR 0.94, p = 0.45, treatment 102 of 156 (65.4%), control 83 of 120 (69.2%).
risk of no recovery, 6.0% lower, RR 0.94, p = 0.67, treatment 156, control 133, time to alleviation of symptoms.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.