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0 0.5 1 1.5 2+ Mortality 70% Improvement Relative Risk Death/hospitalization -30% Death/hospitalization (b) 22% Recovery -6% c19colchicine.com Dorward et al. Colchicine for COVID-19 RCT LATE TREATMENT Favors colchicine Favors control
Dorward, 1,301 patient colchicine late treatment RCT: 70% lower mortality [p=0.43], 30% higher combined mortality/hospitalization [p=0.66], and 6% worse recovery [p=0.67] https://c19p.org/dorward
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Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
Dorward et al., British Journal of General Practice, doi:10.3399/BJGP.2022.0083 (preprint 9/23/2021)
23 Sep 2021    Source   PDF   Share   Tweet
Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580.
risk of death, 69.7% lower, RR 0.30, p = 0.43, treatment 0 of 156 (0.0%), control 1 of 120 (0.8%), NNT 120, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of death/hospitalization, 29.8% higher, RR 1.30, p = 0.66, treatment 6 of 156 (3.8%), control 4 of 133 (3.0%), odds ratio converted to relative risk, concurrent randomisation.
risk of death/hospitalization, 22.1% lower, RR 0.78, p = 0.59, treatment 6 of 156 (3.8%), control 119 of 1,145 (10.4%), odds ratio converted to relative risk, including control patients before the colchicine arm started.
risk of no recovery, 6.4% higher, HR 1.06, p = 0.67, treatment 156, control 133, time to alleviation of symptoms, concurrent randomisation.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Dorward et al., 9/23/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 21 authors, study period 4 March, 2021 - 26 May, 2021, average treatment delay 6.0 days.
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