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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death/hospitalization -30% Improvement Relative Risk Death/hospitalization (b) 22% Progression 6% Recovery 6% c19colchicine.com/dorward.html Favors colchicine Favors control
23 September 2021 - Late treatment study
Colchicine for COVID-19 in adults in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
Dorward et al., medRxiv, doi:2021.09.20.21263828 (Preprint)
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Late treatment RCT with 156 colchicine patients in the UK, showing no significant differences. ISRCTN86534580.
risk of death/hospitalization, 29.8% higher, RR 1.30, p = 0.66, treatment 6 of 156 (3.8%), control 4 of 133 (3.0%), odds ratio converted to relative risk, concurrent randomisation.
risk of death/hospitalization, 22.1% lower, RR 0.78, p = 0.59, treatment 6 of 156 (3.8%), control 119 of 1,145 (10.4%), NNT 15, odds ratio converted to relative risk, including control patients before the colchicine arm started.
risk of progression, 6.0% lower, RR 0.94, p = 0.45, treatment 102 of 156 (65.4%), control 83 of 120 (69.2%), NNT 26.
risk of no recovery, 6.0% lower, RR 0.94, p = 0.67, treatment 156, control 133, time to alleviation of symptoms.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Dorward et al., 9/23/2021, Randomized Controlled Trial, United Kingdom, Europe, preprint, 21 authors.
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