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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 19% Improvement Relative Risk Mechanical ventilation 15% ICU admission 1% c19colchicine.com/gaitanduarte.html Favors colchicine Favors control
10 July 2021 - Late treatment study
Effectiveness of Rosuvastatin plus Colchicine, Emtricitabine/Tenofovir and a combination of them in Hospitalized Patients with SARS Covid-19
Gaitán-Duarte et al., medRxiv, doi:10.1101/2021.07.06.21260085 (Preprint)
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RCT 633 hospitalized patients in Colombia, 153 treated with colchicine + rosuvastatin, not showing statistically significant differences in outcomes. Improved results were seen with the combination of emtricitabine/tenofovir disoproxil + rosuvastatin + colchicine. NCT04359095.
risk of death, 19.0% lower, RR 0.81, p = 0.43, treatment 22 of 153 (14.4%), control 28 of 161 (17.4%), NNT 33, adjusted per study, 28 days.
risk of mechanical ventilation, 15.0% lower, RR 0.85, p = 0.15, treatment 27 of 136 (19.9%), control 27 of 140 (19.3%), adjusted per study.
risk of ICU admission, 1.0% lower, RR 0.99, p = 0.97, treatment 19 of 113 (16.8%), control 18 of 114 (15.8%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Gaitán-Duarte et al., 7/10/2021, Randomized Controlled Trial, Colombia, South America, preprint, 17 authors, average treatment delay 10.0 days, this trial uses multiple treatments in the treatment arm (combined with rosuvastatin) - results of individual treatments may vary.
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