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0 0.5 1 1.5 2+ Mortality 22% Improvement Relative Risk c19colchicine.com Gaitán-Duarte et al. NCT04359095 Colchicine RCT LATE Favors colchicine Favors control
Gaitán-Duarte, 314 patient colchicine late treatment RCT: 22% lower mortality [p=0.38] https://c19p.org/gaitanduarte
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Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19: a pragmatic, open-label randomized trial
Gaitán-Duarte et al., eClinicalMedicine, doi:10.1016/j.eclinm.2021.101242, NCT04359095 (history)
10 Jul 2021    Source   PDF   Share   Tweet
RCT 633 hospitalized patients in Colombia, 153 treated with colchicine + rosuvastatin, not showing statistically significant differences in outcomes. Improved results were seen with the combination of emtricitabine/tenofovir disoproxil + rosuvastatin + colchicine. NCT04359095 (history).
risk of death, 22.0% lower, HR 0.78, p = 0.38, treatment 22 of 153 (14.4%), control 28 of 161 (17.4%), NNT 33, adjusted per study, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gaitán-Duarte et al., 10 Jul 2021, Randomized Controlled Trial, Colombia, peer-reviewed, 17 authors, average treatment delay 10.0 days, this trial uses multiple treatments in the treatment arm (combined with rosuvastatin) - results of individual treatments may vary, trial NCT04359095 (history).
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