RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, mean 9 days after symptom onset. Baseline oxygen requirements unknown (data is provided but combined with "none"). ISRCTN 50189673. NCT04381936.
Horby et al., 5/18/2021, Randomized Controlled Trial, United Kingdom, Uk, preprint, 35 authors.
risk of death, 1.0% higher, RR 1.01, p = 0.77, treatment 1173 of 5610 (20.9%), control 1190 of 5730 (20.8%).
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.