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0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk Recovery 44% c19colchicine.com Manenti et al. Colchicine for COVID-19 LATE TREATMENT Favors colchicine Favors control
Manenti, 141 patient colchicine late treatment study: 76% lower mortality [p=0.005] and 44% improved recovery [p=0.05] https://c19p.org/manenti
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Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study
Manenti et al., PLOS ONE, doi:10.1371/journal.pone.0248276
24 Mar 2021    Source   PDF   Share   Tweet
IPTW retrospective 141 COVID-19 patients (83% hospitalized), 71 treated with colchicine and 70 matched control patients, showing lower mortality and faster recovery with treatment.
risk of death, 76.0% lower, HR 0.24, p = 0.005, treatment 71, control 70, adjusted per study, propensity score weighting.
risk of no recovery, 44.4% lower, RR 0.56, p = 0.048, treatment 71, control 70, adjusted per study, propensity score weighting.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Manenti et al., 3/24/2021, retrospective, Italy, Europe, peer-reviewed, 24 authors, study period 1 March, 2020 - 10 April, 2020.
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This PaperColchicineAll
Late treatment
is less effective
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