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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 76% Improvement Relative Risk Recovery 44% Colchicine  Manenti et al.  LATE TREATMENT Is late treatment with colchicine beneficial for COVID-19? Retrospective 141 patients in Italy (March - April 2020) Lower mortality with colchicine (p=0.0054) c19early.org Manenti et al., PLOS ONE, March 2021 Favors colchicine Favors control

Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study

Manenti et al., PLOS ONE, doi:10.1371/journal.pone.0248276
Mar 2021  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000024 from 52 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
IPTW retrospective 141 COVID-19 patients (83% hospitalized), 71 treated with colchicine and 70 matched control patients, showing lower mortality and faster recovery with treatment.
risk of death, 76.0% lower, HR 0.24, p = 0.005, treatment 71, control 70, adjusted per study, propensity score weighting.
risk of no recovery, 44.4% lower, RR 0.56, p = 0.048, treatment 71, control 70, adjusted per study, inverted to make RR<1 favor treatment, propensity score weighting.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Manenti et al., 24 Mar 2021, retrospective, Italy, peer-reviewed, 24 authors, study period 1 March, 2020 - 10 April, 2020, dosage 1mg days 1-21.
This PaperColchicineAll
Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study
Lucio Manenti, Umberto Maggiore, Enrico Fiaccadori, Tiziana Meschi, Anna Degli Antoni, Antonio Nouvenne, Andrea Ticinesi, Nicoletta Cerundolo, Beatrice Prati, Marco Delsante, Ilaria Gandoflini, Lorenzo Donghi, Micaela Gentile, Maria Teresa Farina, Vincenzo Oliva, Cristina Zambrano, Giuseppe Regolisti, Alessandra Palmisano, Caterina Caminiti, Enrico Cocchi, Carlo Ferrari, Leonardo V Riella, Paolo Cravedi, Licia Peruzzi
PLOS ONE, doi:10.1371/journal.pone.0248276
Objectives Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. We hypothesized that colchicine, by counteracting proinflammatory pathways implicated in the uncontrolled inflammatory response of COVID-19 patients, reduces pulmonary complications, and improves survival. Methods This retrospective study included 71 consecutive COVID-19 patients (hospitalized with pneumonia on CT scan or outpatients) who received colchicine and compared with 70 control patients who did not receive colchicine in two serial time periods at the same institution. We used inverse probability of treatment propensity-score weighting to examine differences in mortality, clinical improvement (using a 7-point ordinary scale), and inflammatory markers between the two groups. Results Amongst the 141 hospitalized), 70 (50%) received colchicine. The 21-day crude cumulative mortality was 7.5% in the colchicine group and 28.5% in the control group (P = 0.006; adjusted hazard ratio: 0.24 [95%CI: 0.09 to 0.67]); 21-day
Supporting information S1 Table. Demographic and clinical characteristics of the study population after propen Author Contributions Conceptualization: Lucio Manenti, Umberto Maggiore, Paolo Cravedi, Licia Peruzzi. Data curation: Lucio Manenti. Formal analysis: Lucio Manenti. Writing -original draft: Lucio Manenti, Umberto Maggiore, Paolo Cravedi. Writing -review & editing: Umberto Maggiore, Enrico Fiaccadori, Tiziana Meschi, Anna Degli Antoni, Antonio Nouvenne, Andrea Ticinesi, Nicoletta Cerundolo, Beatrice Prati, Marco Delsante, Ilaria Gandoflini, Lorenzo Donghi, Micaela Gentile, Maria Teresa Farina, Vincenzo Oliva, Cristina Zambrano, Giuseppe Regolisti, Alessandra Palmisano, Caterina Caminiti, Enrico Cocchi, Carlo Ferrari, Leonardo V. Riella, Paolo Cravedi, Licia Peruzzi.
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Late treatment
is less effective
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