Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study
V Yu. Mareev, Ya. A Orlova, A G Plisyk, E P Pavlikova, Z A Akopyan, S T Matskeplishvili, P S Malakhov, T N Krasnova, E M Seredenina, A V Potapenko, M A Agapov, D A Asratyan, L I Dyachuk, L M Samokhodskaya, Е А Mershina, V E Sinitsyn, P V Pakhomov, E A Zhdanova, Yu. V Mareev, Yu. L Begrambekova, А А Kamalov
Kardiologiia, doi:10.18087/cardio.2021.2.n1560
Conclusions Colchicine 1 mg for 1-3 days followed by 0.5 mg / day for 14 days is effective as a proactive antiinflammatory therapy in hospitalized patients with COVID-19 and viral pneumonia. The management of such patients without proactive anti-inflammatory therapy is likely to be unreasonable and may worsen the course of COVID-19. However, the findings should be treated with caution, given the small size of the trial.
Additional materials Boxplot graphs with the dynamics of SHOCS-COVID, NEWS-2, SPO 2 and others are available in the section «Additional materials» to the article on the website of the journal.
Limitations of this study No appropriate randomization, few patients.
No conflict of interest is reported. The article was received on 08/02/2021 R EFER ENCES
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