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0 0.5 1 1.5 2+ Mortality 80% Improvement Relative Risk ΔSHOCS-COVID 50% primary SHOCS-COVID 71% NEWS-2 67% Hospitalization time 26% c19colchicine.com Mareev et al. Colchicine for COVID-19 LATE TREATMENT Favors colchicine Favors control
Mareev, 43 patient colchicine late treatment study: 50% improved recovery [p=0.06] and 26% shorter hospitalization [p=0.08] https://c19p.org/mareev2
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Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study
Mareev et al., Kardiologiia, doi:10.18087/cardio.2021.2.n1560
28 Feb 2021    Source   PDF   Share   Tweet
Small trial with 21 colchicine patients and 22 control patients in Russia, showing improved recovery with treatment. The trial was originally an RCT, however randomization to the control arm was stopped after 5 patients, and 17 retrospective patients were added for comparison.
risk of death, 79.6% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 22 (9.1%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
ΔSHOCS-COVID, 50.0% lower, RR 0.50, p = 0.06, treatment 21, control 22, ΔSHOCS-COVID score, primary outcome.
SHOCS-COVID, 71.4% lower, RR 0.29, p = 0.002, treatment 21, control 22, SHOCS-COVID score.
NEWS-2, 66.7% lower, RR 0.33, p = 0.06, treatment 21, control 22, inverted to make RR<1 favor treatment, NEWS-2 score.
hospitalization time, 25.7% lower, relative time 0.74, p = 0.08, treatment 21, control 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mareev et al., 28 Feb 2021, retrospective, Russia, peer-reviewed, 21 authors.
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