Mareev: Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study

Mareev, 43 patient colchicine late treatment study: 50% improved recovery [p=0.06] and 26% shorter hospitalization [p=0.08] https://c19p.org/mareev2

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Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study

Mareev et al., Kardiologiia, doi:10.18087/cardio.2021.2.n1560

28 Feb 2021 Source PDF Share Tweet

Small trial with 21 colchicine patients and 22 control patients in Russia, showing improved recovery with treatment. The trial was originally an RCT, however randomization to the control arm was stopped after 5 patients, and 17 retrospective patients were added for comparison.

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risk of death, 79.6% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 22 (9.1%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).

ΔSHOCS-COVID, 50.0% lower, RR 0.50, p = 0.06, treatment 21, control 22, ΔSHOCS-COVID score, primary outcome.

SHOCS-COVID, 71.4% lower, RR 0.29, p = 0.002, treatment 21, control 22, SHOCS-COVID score.

NEWS-2, 66.7% lower, RR 0.33, p = 0.06, treatment 21, control 22, inverted to make RR<1 favor treatment, NEWS-2 score.

hospitalization time, 25.7% lower, relative time 0.74, p = 0.08, treatment 21, control 22.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Mareev et al., 28 Feb 2021, retrospective, Russia, peer-reviewed, 21 authors.

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