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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 80% Improvement Relative Risk ΔSHOCS-COVID 50% primary SHOCS-COVID 71% NEWS-2 67% Hospitalization time 26% Colchicine for COVID-19  Mareev et al.  LATE TREATMENT Is late treatment with colchicine beneficial for COVID-19? Retrospective 43 patients in Russia Lower mortality (p=0.49) and improved recovery (p=0.064), not sig. c19early.org Mareev et al., Kardiologiia, February 2021 Favors colchicine Favors control

Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study

Mareev et al., Kardiologiia, doi:10.18087/cardio.2021.2.n1560
Feb 2021  
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Colchicine for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now known with p = 0.00000024 from 52 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,900+ studies for 60+ treatments. c19early.org
Small trial with 21 colchicine patients and 22 control patients in Russia, showing improved recovery with treatment. The trial was originally an RCT, however randomization to the control arm was stopped after 5 patients, and 17 retrospective patients were added for comparison.
risk of death, 79.6% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 22 (9.1%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
ΔSHOCS-COVID, 50.0% lower, RR 0.50, p = 0.06, treatment 21, control 22, ΔSHOCS-COVID score, primary outcome.
SHOCS-COVID, 71.4% lower, RR 0.29, p = 0.002, treatment 21, control 22, SHOCS-COVID score.
NEWS-2, 66.7% lower, RR 0.33, p = 0.06, treatment 21, control 22, inverted to make RR<1 favor treatment, NEWS-2 score.
hospitalization time, 25.7% lower, relative time 0.74, p = 0.08, treatment 21, control 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mareev et al., 28 Feb 2021, retrospective, Russia, peer-reviewed, 21 authors, dosage 1mg days 1-3.
This PaperColchicineAll
Proactive anti-inflammatory therapy with colchicine in the treatment of advanced stages of new coronavirus infection. The first results of the COLORIT study
V Yu. Mareev, Ya. A Orlova, A G Plisyk, E P Pavlikova, Z A Akopyan, S T Matskeplishvili, P S Malakhov, T N Krasnova, E M Seredenina, A V Potapenko, M A Agapov, D A Asratyan, L I Dyachuk, L M Samokhodskaya, Е А Mershina, V E Sinitsyn, P V Pakhomov, E A Zhdanova, Yu. V Mareev, Yu. L Begrambekova, А А Kamalov
Kardiologiia, doi:10.18087/cardio.2021.2.n1560
Conclusions Colchicine 1 mg for 1-3 days followed by 0.5 mg / day for 14 days is effective as a proactive antiinflammatory therapy in hospitalized patients with COVID-19 and viral pneumonia. The management of such patients without proactive anti-inflammatory therapy is likely to be unreasonable and may worsen the course of COVID-19. However, the findings should be treated with caution, given the small size of the trial.
Additional materials Boxplot graphs with the dynamics of SHOCS-COVID, NEWS-2, SPO 2 and others are available in the section «Additional materials» to the article on the website of the journal. Limitations of this study No appropriate randomization, few patients. No conflict of interest is reported. The article was received on 08/02/2021 R EFER ENCES
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Late treatment
is less effective
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