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0 0.5 1 1.5 2+ Mortality 83% primary Improvement Relative Risk Hospitalization time 35% c19colchicine.com Mostafaie et al. NCT04392141 Colchicine RCT LATE Favors colchicine Favors control
Mostafaie, 120 patient colchicine late treatment RCT: 83% lower mortality [p=0.11] and 35% shorter hospitalization [p=0.0001] https://c19p.org/mostafaie
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Colchicine Plus Phenolic Monoterpenes to Treat COVID-19
Mostafaie et al., ClinicalTrials.gov, NCT04392141 (Preprint)
20 Apr 2021    Source   PDF   Share   Tweet
RCT with 60 patients treated with colchicine and phenolic monoterpenes and 60 control patients in Iran, showing lower mortality with treatment. NCT04392141.
risk of death, 83.3% lower, RR 0.17, p = 0.11, treatment 1 of 60 (1.7%), control 6 of 60 (10.0%), NNT 12, primary outcome.
hospitalization time, 34.7% lower, relative time 0.65, p < 0.001, treatment 59, control 54.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Mostafaie et al., 4/20/2021, Randomized Controlled Trial, Iran, Middle East, preprint, 1 author, this trial uses multiple treatments in the treatment arm (combined with phenolic monoterpenes) - results of individual treatments may vary, trial NCT04392141.
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Late treatment
is less effective
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