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00.250.50.7511.251.51.752+Deftereos (RCT)77%0.23 [0.03-1.97]death1/554/50Improvement, RR [CI]TreatmentControlLopes (DB RCT)80%0.20 [0.01-4.03]death0/362/36Brunetti73%0.27 [0.08-0.89]death3/3311/33Scarsi85%0.15 [0.06-0.37]death122140Pinzón35%0.65 [0.34-1.21]death14/14523/156Sandhu42%0.58 [0.40-0.85]death16/3463/78Rodriguez-Nava6%0.94 [0.61-1.47]death16/5285/261Tardif (DB RCT)44%0.56 [0.19-1.67]death5/2,2359/2,253Horby (RCT)-1%1.01 [0.93-1.10]death1,173/5,6101,190/5,730Tau​2 = 0.19; I​2 = 76.0%Late treatment43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvementAll studies43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvement9 colchicine COVID-19 studiesc19colchicine.com 7/28/21Tau​2 = 0.19; I​2 = 76.0%; Z = 2.77 (p = 0.0028)Effect extraction pre-specifiedLower RiskIncreased Risk 00.250.50.7511.251.51.752+Deftereos (RCT)77%0.23 [0.03-1.97]1/554/50Improvement, RR [CI]TreatmentControlLopes (DB RCT)80%0.20 [0.01-4.03]0/362/36Brunetti73%0.27 [0.08-0.89]3/3311/33Scarsi85%0.15 [0.06-0.37]122140Pinzón35%0.65 [0.34-1.21]14/14523/156Sandhu42%0.58 [0.40-0.85]16/3463/78Rodriguez-Nava6%0.94 [0.61-1.47]16/5285/261Tardif (DB RCT)44%0.56 [0.19-1.67]5/2,2359/2,253Horby (RCT)-1%1.01 [0.93-1.10]1,173/5,6101,190/5,730Tau​2 = 0.19; I​2 = 76.0%Late treatment43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvementAll studies43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvement9 colchicine COVID-19 mortality resultsc19colchicine.com 7/28/21Tau​2 = 0.19; I​2 = 76.0%; Z = 2.77 (p = 0.0028)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Lopes (DB RCT)50%0.50 [0.10-2.56]2/364/36Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Late treatment50%0.50 [0.10-2.56]2/364/3650% improvementAll studies50%0.50 [0.10-2.56]2/364/3650% improvement1 colchicine COVID-19 ICU resultc19colchicine.com 7/28/21Tau​2 = 0.00; I​2 = 0.0%; Z = 0.83 (p = 0.2)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Tardif (DB RCT)20%0.80 [0.61-1.03]hosp.101/2,235128/2,253Improvement, RR [CI]TreatmentControlTau​2 = 0.00; I​2 = 0.0%Late treatment20%0.80 [0.61-1.03]101/2,235128/2,25320% improvementAll studies20%0.80 [0.62-1.03]101/2,235128/2,25320% improvement1 colchicine COVID-19 hospitalization resultc19colchicine.com 7/28/21Tau​2 = 0.00; I​2 = 0.0%; Z = 1.72 (p = 0.042)Lower RiskIncreased Risk 00.250.50.7511.251.51.752+Deftereos (RCT)77%0.23 [0.03-1.97]death1/554/50Improvement, RR [CI]TreatmentControlLopes (DB RCT)80%0.20 [0.01-4.03]death0/362/36Brunetti73%0.27 [0.08-0.89]death3/3311/33Scarsi85%0.15 [0.06-0.37]death122140Pinzón35%0.65 [0.34-1.21]death14/14523/156Sandhu42%0.58 [0.40-0.85]death16/3463/78Rodriguez-Nava6%0.94 [0.61-1.47]death16/5285/261Tardif (DB RCT)44%0.56 [0.19-1.67]death5/2,2359/2,253Horby (RCT)-1%1.01 [0.93-1.10]death1,173/5,6101,190/5,730Tau​2 = 0.19; I​2 = 76.0%Late treatment43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvementAll studies43%0.57 [0.38-0.85]1,228/8,3221,387/8,73743% improvement9 colchicine COVID-19 serious outcomesc19colchicine.com 7/28/21Tau​2 = 0.19; I​2 = 76.0%; Z = 2.77 (p = 0.0028)Effect extraction pre-specifiedLower RiskIncreased Risk 00.250.50.7511.251.51.752+Deftereos (RCT)77%0.23 [0.03-1.97]death1/554/50Improvement, RR [CI]TreatmentControlDeftereos (RCT)82%0.18 [0.02-1.50]ventilation1/555/50Deftereos (RCT)87%0.13 [0.01-0.97]progression1/557/50Lopes (DB RCT)80%0.20 [0.01-4.03]death0/362/36Lopes (DB RCT)50%0.50 [0.10-2.56]ICU2/364/36Brunetti73%0.27 [0.08-0.89]death3/3311/33Brunetti73%0.27 [0.08-0.89]no disch.3/3311/33Scarsi85%0.15 [0.06-0.37]death122140Pinzón35%0.65 [0.34-1.21]death14/14523/156Sandhu42%0.58 [0.40-0.85]death16/3463/78Sandhu53%0.47 [0.33-0.67]ventilation16/3468/68Sandhu42%0.58 [0.40-0.85]no disch.16/3463/78Rodriguez-Nava6%0.94 [0.61-1.47]death16/5285/261Tardif (DB RCT)44%0.56 [0.19-1.67]death5/2,2359/2,253Tardif (DB RCT)47%0.53 [0.25-1.09]ventilation11/2,23521/2,253Tardif (DB RCT)20%0.80 [0.61-1.03]hosp.101/2,235128/2,253Horby (RCT)-1%1.01 [0.93-1.10]death1,173/5,6101,190/5,730colchicine COVID-19 outcomesc19colchicine.com 7/28/21Lower RiskIncreased Risk
Please send us corrections, updates, or comments. Vaccines and treatments are both extremely valuable and complementary. All practical, effective, and safe means should be used. Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. Denying the efficacy of any method increases the risk of COVID-19 becoming endemic; and increases mortality, morbidity, and collateral damage. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. Treatment protocols for physicians are available from the FLCCC.
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