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0 0.5 1 1.5 2+ Mortality 80% Improvement Relative Risk Ventilation 80% ICU admission 51% 7-point scale 87% primary 7-point scale (b) 80% Hospitalization time -15% c19colchicine.com Pascual-Figal et al. NCT04350320 Colchicine RCT LATE Favors colchicine Favors control
Pascual-Figal, 103 patient colchicine late treatment RCT: 80% lower mortality [p=0.24], 80% lower ventilation [p=0.24], 87% improved 7-point scale results [p=0.03], and 15% longer hospitalization [p=0.34] https://c19p.org/pascualfigal
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Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID)
Pascual-Figal et al., International Journal of General Medicine, doi:10.2147/IJGM.S329810, NCT04350320 (history)
11 Sep 2021    Source   PDF   Share   Tweet
RCT with 52 colchicine patients and 51 control patients, showing lower risk of clinical deterioration with treatment. COL-COVID. NCT04350320 (history).
risk of death, 80.2% lower, RR 0.20, p = 0.24, treatment 0 of 52 (0.0%), control 2 of 51 (3.9%), NNT 26, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of mechanical ventilation, 80.2% lower, RR 0.20, p = 0.24, treatment 0 of 52 (0.0%), control 2 of 51 (3.9%), NNT 26, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 51.0% lower, RR 0.49, p = 0.44, treatment 2 of 52 (3.8%), control 4 of 51 (7.8%), NNT 25.
risk of 7-point scale, 87.5% lower, RR 0.13, p = 0.03, treatment 3 of 52 (5.8%), control 7 of 51 (13.7%), adjusted per study, odds ratio converted to relative risk, deterioration ≥1 point, multivariable, primary outcome.
risk of 7-point scale, 80.2% lower, RR 0.20, p = 0.24, treatment 0 of 52 (0.0%), control 2 of 51 (3.9%), NNT 26, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), deterioration ≥2 points.
hospitalization time, 14.6% higher, relative time 1.15, p = 0.34, treatment 52, control 51.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pascual-Figal et al., 11 Sep 2021, Randomized Controlled Trial, Spain, peer-reviewed, 14 authors, study period 30 April, 2020 - 4 December, 2020, trial NCT04350320 (history).
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