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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 79% Improvement Relative Risk Improvement 85% c19colchicine.com Pimenta Bonifácio et al. NCT04724629 Colchicine RCT LATE Favors colchicine Favors control
Pimenta Bonifácio, 30 patient colchicine late treatment RCT: 85% better improvement [p=0.23] https://c19p.org/pimentabonifacio
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Efficacy and safety of Ixekizumab vs. low-dose IL-2 vs. Colchicine vs. standard of care on the treatment of patients hospitalized with moderate to critical Covid-19: a pilot randomized clinical trial (STRUCK: Survival Trial Using Cytokine Inhibitors)
Pimenta Bonifácio et al., SSRN Electronic Journal, doi:10.2139/ssrn.4095747
28 Apr 2022    Source   PDF   Share   Tweet
Open label RCT late stage hospitalized patients in Brazil with 14 colchicine and 16 SOC patients, showing lower mortality and improved recovery with treatment, without statistical significance. Authors note that the colchicine group had one patient with SOFA ≥7 vs. zero for SOC, however both groups had one patient intubated and SOC had more patients not requiring high-flow oxygen (12 vs. 8).
risk of death, 78.9% lower, RR 0.21, p = 0.49, treatment 0 of 14 (0.0%), control 2 of 16 (12.5%), NNT 8.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no improvement, 84.9% lower, RR 0.15, p = 0.23, treatment 0 of 14 (0.0%), control 3 of 16 (18.8%), NNT 5.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pimenta Bonifácio et al., 4/28/2022, Randomized Controlled Trial, Brazil, South America, peer-reviewed, 20 authors, trial NCT04724629.
Contact: fbellissimo@usp.br, livia_pb@usp.br.
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