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Colchicine study #10   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -1% Imp. Relative Risk, 95% CI Mechanical ventilation -18% Combined intubation/de.. -2% Hospital discharge -2% Recovery Collaborative Group: Colchicine in patients admitted to hospital wi.. c19colchicine.com/recoveryc.html Favors colchicine Favors control
5/18 Late treatment study
Recovery Collaborative Group, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00435-5 (preprint 5/18/2021) (Peer Reviewed)
Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, mean 9 days after symptom onset. Baseline oxygen requirements unknown (data is provided but combined with "none"). ISRCTN 50189673. NCT04381936.
risk of death, 1.0% higher, RR 1.01, p = 0.77, treatment 1,173 of 5,610 (20.9%), control 1,190 of 5,730 (20.8%).
risk of mechanical ventilation, 18.0% higher, RR 1.18, p = 0.06, treatment 259 of 3,815 (6.8%), control 228 of 3,962 (5.8%).
risk of combined intubation/death, 2.0% higher, RR 1.02, p = 0.47, treatment 1,344 of 5,342 (25.2%), control 1,343 of 5,469 (24.6%).
risk of no hospital discharge, 2.0% higher, RR 1.02, p = 0.44, treatment 1,709 of 5,610 (30.5%), control 1,698 of 5,730 (29.6%).
Recovery Collaborative Group et al., 5/18/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 35 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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