Recovery Collaborative Group: Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Recovery Collaborative Group, 11,340 patient colchicine late treatment RCT: 1% higher mortality [p=0.77], 18% higher ventilation [p=0.06], 2% higher combined mortality/intubation [p=0.47], and 2% lower hospital discharge [p=0.44] https://c19p.org/recoveryc

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Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Recovery Collaborative Group, The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00435-5 (preprint 5/18/2021)

18 May 2021 Source PDF Share Tweet

RCT with 5,610 colchicine and 5,730 control patients showing mortality RR 1.01 [0.93-1.10]. Very late stage treatment, median 9 days after symptom onset. Baseline oxygen requirements unknown (data is provided but combined with "none"). ISRCTN 50189673. NCT04381936.

risk of death, 1.0% higher, RR 1.01, p = 0.77, treatment 1,173 of 5,610 (20.9%), control 1,190 of 5,730 (20.8%).

risk of mechanical ventilation, 18.0% higher, RR 1.18, p = 0.06, treatment 259 of 3,815 (6.8%), control 228 of 3,962 (5.8%).

risk of death/intubation, 2.0% higher, RR 1.02, p = 0.47, treatment 1,344 of 5,342 (25.2%), control 1,343 of 5,469 (24.6%).

risk of no hospital discharge, 2.0% higher, RR 1.02, p = 0.44, treatment 1,709 of 5,610 (30.5%), control 1,698 of 5,730 (29.6%).

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Recovery Collaborative Group et al., 5/18/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 35 authors, average treatment delay 9.0 days, trial NCT04381936.

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Late treatment
is less effective

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