Retrospective 122 colchicine patients and 140 control patients in Italy, showing lower mortality with treatment.
Scarsi et al., 9/14/2020, retrospective, Italy, Europe, peer-reviewed, 28 authors.
risk of death, 84.9% lower, RR 0.15, p < 0.001, treatment 122, control 140.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.