Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome

9/14 Late treatment study

Scarsi et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-217712 (Peer Reviewed)
Association between treatment with colchicine and improved survival in a single-centre cohort of adult hospitalised patients with COVID-19 pneumonia and acute respiratory distress syndrome

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Retrospective 122 colchicine patients and 140 control patients in Italy, showing lower mortality with treatment.

Scarsi et al., 9/14/2020, retrospective, Italy, Europe, peer-reviewed, 28 authors.

risk of death, 84.9% lower, RR 0.15, p < 0.001, treatment 122, control 140.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.

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