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0 0.5 1 1.5 2+ Mortality 44% Improvement Relative Risk Death/hospitalization 20% primary Ventilation 47% Hospitalization 20% c19colchicine.com Tardif et al. NCT04322682 Colchicine RCT LATE TREATMENT Favors colchicine Favors control
Tardif, 4,488 patient colchicine late treatment RCT: 44% lower mortality [p=0.3], 20% lower combined mortality/hospitalization [p=0.08], 47% lower ventilation [p=0.09], and 20% lower hospitalization [p=0.09] https://c19p.org/tardif
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Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
Tardif et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00222-8 (preprint 1/27)
27 Jan 2021    Source   PDF   Share   Tweet
RCT for relatively low risk outpatients, 2235 treated with colchicine a mean of 5.3 days after the onset of symptoms, and 2253 controls, showing lower mortality, ventilation, and hospitalization with treatment. NCT04322682.
risk of death, 43.9% lower, RR 0.56, p = 0.30, treatment 5 of 2,235 (0.2%), control 9 of 2,253 (0.4%), NNT 569, odds ratio converted to relative risk.
risk of death/hospitalization, 20.0% lower, RR 0.80, p = 0.08, treatment 104 of 2,235 (4.7%), control 131 of 2,253 (5.8%), NNT 86, odds ratio converted to relative risk, primary outcome.
risk of mechanical ventilation, 46.8% lower, RR 0.53, p = 0.09, treatment 11 of 2,235 (0.5%), control 21 of 2,253 (0.9%), NNT 227, odds ratio converted to relative risk.
risk of hospitalization, 20.0% lower, RR 0.80, p = 0.09, treatment 101 of 2,235 (4.5%), control 128 of 2,253 (5.7%), NNT 86, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Tardif et al., 1/27/2021, Double Blind Randomized Controlled Trial, Canada, North America, peer-reviewed, 44 authors, average treatment delay 5.3 days, trial NCT04322682.
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This PaperColchicineAll
Late treatment
is less effective
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