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Colchicine study #8 of 9   All Outcomes
1/27 Late treatment study
Tardif et al., The Lancet Respiratory Medicine, doi:10.1016/S2213-2600(21)00222-8 (preprint 1/27) (Peer Reviewed)
Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial
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RCT for relatively low risk outpatients, 2235 treated with colchicine a mean of 5.3 days after the onset of symptoms, and 2253 controls, showing lower mortality, ventilation, and hospitalization with treatment. NCT04322682.

Tardif et al., 1/27/2021, Double Blind Randomized Controlled Trial, Canada, North America, peer-reviewed, 44 authors.
risk of death, 43.9% lower, RR 0.56, p = 0.30, treatment 5 of 2235 (0.2%), control 9 of 2253 (0.4%), odds ratio converted to relative risk.
risk of mechanical ventilation, 46.8% lower, RR 0.53, p = 0.09, treatment 11 of 2235 (0.5%), control 21 of 2253 (0.9%), odds ratio converted to relative risk.
risk of hospitalization, 20.0% lower, RR 0.80, p = 0.07, treatment 101 of 2235 (4.5%), control 128 of 2253 (5.7%), odds ratio converted to relative risk.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical signficance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All 9 studies   All Outcomes
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