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0 0.5 1 1.5 2+ Mortality 23% Improvement Relative Risk c19colchicine.com Topless et al. Colchicine for COVID-19 Prophylaxis Favors colchicine Favors control
Topless, 341,398 patient colchicine prophylaxis study: 23% lower mortality [p=0.12] https://c19p.org/topless
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Gout and the risk of COVID-19 diagnosis and death in the UK Biobank: a population-based study
Topless et al., The Lancet Rheumatology, doi:10.1016/S2665-9913(21)00401-X
28 Jan 2022    Source   PDF   Share   Tweet
UK Biobank retrospective showing a higher risk of COVID-19 cases and mortality for patients with gout. Among patients with gout, mortality risk was lower for those on colchicine, OR 1.06 [0.60-1.89], compared to those without colchicine, OR 1.38 [1.08-1.76].
risk of death, 23.2% lower, OR 0.77, p = 0.12, relative odds for patients with gout, model 2, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Topless et al., 1/28/2022, retrospective, database analysis, United Kingdom, Europe, peer-reviewed, 6 authors.
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