Valerio Pascua, 65 patient colchicine ICU study: 23% lower mortality [p=0.6] and 40% shorter ICU admission [p=0.03] https://c19p.org/valeriopascua
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A multi-mechanism approach reduces length of stay in the ICU for severe COVID-19 patients
et al., PLOS ONE, doi:10.1371/journal.pone.0245025
Retrospective 65 ICU patients in the USA and Honduras, showing shorter ICU stay with combined treatment including colchicine,
LMWH, tocilizumab, dexamethasone, and methylprednisolone.
LMWH, tocilizumab, dexamethasone, and methylprednisolone.
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risk of death, 22.8% lower, RR 0.77, p = 0.60, treatment 5 of 35 (14.3%), control 12 of 30 (40.0%), NNT 3.9, adjusted per study, odds ratio converted to relative risk, multivariable.
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ICU time, 39.9% lower, relative time 0.60, p = 0.03, treatment 35, control 30, adjusted per study, multivariable.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Valerio Pascua et al., 7 Jan 2021, retrospective, multiple countries, peer-reviewed, 19 authors, study period 10 June, 2020 - 6 August, 2020, average treatment delay 6.1 days, this trial uses multiple treatments in the treatment arm (combined with LMWH, tocilizumab, dexamethasone, methylprednisolone) - results of individual treatments may vary.
Late treatment
is less effective
is less effective
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